Sirisha Vadali, MD

Sirisha Vadali, MD, is a board-certified non-invasive cardiologist and advanced lipidologist specializing in cardiometabolic medicine and women’s heart health. She serves as program director for HonorHealth’s Cardiometabolic Program and is part of the HonorHealth Women’s Heart Health team. 

Dr. Vadali provides advanced cardiometabolic care using tools such as NMR lipid testing, ApoB and particle sub-fractionation, coronary calcium scoring and genetic testing for familial hypercholesterolemia. She has specialized expertise in managing complex lipid disorders including elevated lipoprotein(a), mixed dyslipidemia and homozygous familial hypercholesterolemia. Her care approach includes the use of GLP-1 receptor agonists, precision diagnostics and evidence-based prevention strategies.  

Her clinical focus also includes cardiometabolic syndrome, hypertension, diabetes management and women’s cardiovascular health, particularly sex-specific risk assessment and pregnancy-related impacts. Dr. Vadali emphasizes lifestyle medicine and personalized risk assessment, working with patients to create sustainable, preventive care plans.  

Known for creating a safe and supportive space, Dr. Vadali empowers patients to improve their heart health through shared decision-making and multidisciplinary care. She integrates advanced therapies with compassionate, individualized treatment to optimize outcomes for high-risk patients.  

Originally from Washington, D.C., Dr. Vadali was inspired to pursue preventive cardiology after witnessing the effects of healthcare disparities and cardiovascular disease in her community. She also serves as a principal investigator in cardiometabolic research.